Endocrine Abstracts

1500 euthyroid patients (1302 females and 198 males, mean age 47.8) presenting with thyroid enlargement were evaluated by fine needle aspiration (FNAC) of the thyroid as the first line investigation. The final cytological or histological diagnosis was determined after surgery (n=556) or clinical follow-up for a minimum period of 2 years (mean 9.5 yrs, range 2-19 years). Goitre type was assessed clinically and classified as diffuse in 184, multinodular in 457 or solitary nodule...

Atrial fibrillation (AF) is the commonest dysrhythmia (after sinus tachycardia) complicating hyperthyroidism. We have previously reported increased vascular mortality in hyperthyroidism and postulate this reflects the prevalence of AF. We recruited a consecutive series of 425 subjects with overt hyperthyroidism (n=334 females, 91 males) and determined the prevalence and outcome of AF. All had 12 lead ECG and 24h Holter monitoring before and after antithyroid treatment with thi...

Thyrotoxicosis is a common disorder which induces many cardiovascular effects and is associated with increased cardiovascular mortality. We recruited 283 consecutive unselected thyrotoxic subjects attending our thyroid clinic and 283 age and sex-matched euthyroid controls. All completed a structured cardiovascular history and examination, resting 12-lead ECG and 24-hour Holter recording. Follow up data on mortality was collected for a year. The median age of the cohorts was 49...

Background: Abnormalities of cardiac autonomic function may contribute to excess vascular mortality reported in treated hyperthyroidism.Aim: To evaluate cardiac autonomic function in hyperthyroidism before and after effective anti-thyroid therapy.Methods: 405 consecutive unselected patients with hyperthyroidism were recruited with 405 age- and sex-matched euthyroid controls for matched comparisons; all had 24-hour Holter monitoring. Patients were reassessed when render...

BackgroundPropylthiouracil treatment of Graves' disease has been postulated to provoke anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis, particularly myeloperoxidase (MPO)-ANCA, however it is unclear whether the abnormal immune environment of autoimmine thyroid disease influences the development of ANCA.MethodsThe occurrence of ANCA and the relationship to thionamide treatment was investigated in 407 patients' with Graves' disease, 200 with Hashimo...